Web30 sep. 2024 · Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA characteristics could be of special interest in the treatment and prevention of insulin resistance (IR), but greater in-depth knowledge on the pathways involved in … WebWe previously demonstrated that trans-10, cis-12 conjugated linoleic acid (CLA) reduced the triglyceride content of human adipocytes by activating mitogen-activated protein kinase kinase/extracellular signal-related kinase (MEK/ERK) signaling via interleukins (IL) 6 and 8. However, the upstream mechanism is unknown. Here we show that CLA increased (≥6 …
Hepatic insulin sensitizing substance: a novel
Web26 nov. 2012 · MIS occurs when the presence of food in the upper gastrointestinal tract activates 2 feeding signals (activation of hepatic parasympathetic nerves and elevation of hepatic glutathione level), and causes insulin to release hepatic insulin sensitizing substance (HISS), which stimulates glucose uptake in skeletal muscle, heart, and kidneys. WebThe liver is a fundamental organ to ensure whole-body homeostasis, allowing for a proper increase in insulin sensitivity from the fast to the postprandial status. Hepatic regulation of glucose metabolism is crucial and has been shown to be modulated by glutathione (GSH) and nitric oxide (NO). However, knowledge of the metabolic action of GSH and NO in … frank teodosio wells fargo tampa fl
Control of hepatocyte metabolism by sympathetic and parasympathetic ...
WebWe recently described the sensory nitrergic nature of the hepatic insulin sensitizing substance (HISS) mechanism linked to postprandial activation of anterior hepatic … Web1 jul. 2001 · we have recently described a novel neurohormonal mechanism by which insulin causes release of a putative hepatic insulin sensitizing substance (HISS) from the liver, dependent on a hepatic parasympathetic- and nitric oxide (NO)-mediated permissive reflex (reviewed in Ref. 3 ). Web2 apr. 2024 · Insulin-sensitizing drugs have an important role in the treatment of patients with type 2 diabetes, and insulin sensitizing effects of drugs developed to primarily address a non-diabetes indication, e.g. NASH, are of great interest within the context of a more holistic treatment approach of metabolic diseases. frank tepedino obituary